structure
P04601 False
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offset
HV1H2 sequence
Number of mutations for residue
chain
domain
short sequence motif
ELM
site of interest
initiator methionine
lipid moiety-binding region
region of interest
Intrinsic disorder score
?
 
|1
|51
|101
|151
|201
M
G
G
K
W
S
K
S
S
V
I
G
W
P
T
V
R
E
R
M
R
R
A
E
P
A
A
D
R
V
G
A
A
S
R
D
L
E
K
H
G
A
I
T
S
S
N
T
A
A
T
N
A
A
C
A
W
L
E
A
Q
E
E
E
E
V
G
F
P
V
T
P
Q
V
P
L
R
P
M
T
Y
K
A
A
V
D
L
S
H
F
L
K
E
K
G
G
L
E
G
L
I
H
S
Q
R
R
Q
D
I
L
D
L
W
I
Y
H
T
Q
G
Y
F
P
D
W
Q
N
Y
T
P
G
P
G
V
R
Y
P
L
T
F
G
W
C
Y
K
L
V
P
V
E
P
D
K
I
E
E
A
N
K
G
E
N
T
S
L
L
H
P
V
S
L
H
G
M
D
D
P
E
R
E
V
L
E
W
R
F
D
S
R
L
A
F
H
H
V
A
R
E
L
H
P
E
Y
F
K
N
C
Nef protein
C-terminal core protein
PxxP; stabilizes the interaction of NEF/MHC-I with host AP1M1; necessary for MHC-I internalization
Di-leucine internalization motif; necessary for CD4 internalization
Diacidic; necessary for CD4 internalization
Might play a role in AP-1 recruitment to the Nef-MHC-I complex
Cleavage; by viral protease
Removed; by host
N-myristoyl glycine; by host
N-terminal; associates with the host plasma membrane
Acidic; stabilizes the interaction of NEF/MHC-I with host AP1M1; necessary for MHC-I internalization and interaction with host PACS1 and PACS2
SH3-binding; interaction with Src family tyrosine kinases
Mediates dimerization, Nef-PTE1 interaction
Binding to ATP6V1H
Necessary for MHC-I internalization
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Click on orange bars in mutation barplot or residue in sequence for detailed mutagenesis information for a residue. All data is mapped to the HXB2 isolate.
Citation : Davey NE*, Satagopam VP*, Santiago-Mozos S*, Villacorta-Martin C, Bharat TA, Schneider R, Briggs JA.
The HIV Mutation Browser: A Resource for Human Immunodeficiency Virus Mutagenesis and Polymorphism Data.
PLoS Comput Biol. 2014 Dec 4;10(12):e1003951. [PubMed | PLoS ]

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